Case Studies about Exploring The Effects Of Social And Relationship Marketing On Behavior Change

Introduction Several researchers from all over the word, going by the clarity of their findings, have come up with conclusions about the change in behavior of an individual. Some of these conclusions have been specific while others contain the kind of precision which leaves us with many unanswered questions. It is therefore logical to explore this matter in order to come up with some dependable information with regard to the dynamics that surround the behavior of consumers. In the business arena, the changes in the behavior of the people in various capacities go along way in affecting   the flow of things within the business surrounding. For instance, workers whose motivations and behaviors towards their responsibilities have been boosted will surely deliver. At the same time, when a business organization has twisted the minds of the customers towards a particular way of doing their things then the behavior of the customers will probably be inclined towards such methods. Just as I have outlined in the general introduction above, a number of factors may affect the changes in behavior of an individual especially in the business arena. In line with that, the main aim of this case study will be to explore the effects that social and relationship marketing has on the behavior of individuals. The main objective of this study shall therefore involve the application of various methodological approaches to dig into the issues of social and relationship marketing. This shall be done with the main target of finding out how these strategies influence the change in behavior of individuals, especially those who have ever been reached. The study shall involve exploring various concepts and theories as well as carrying out the relevant research. This work shall therefore aim at addressing such issues as understanding the social, cultural, technological, economic and psychological factors which affect the behavior of the consumers. The above aims will be sought in line with the two marketing scenarios which I have highlighted above, i.e. the social and the relationship marketing. The conclusion of the study shall involve an establishment of the findings and after comparing them with the theoretical stipulations, I will proceed to make the desired conclusion. Literature review In order to have a deeper understanding of what I shall be handling in this case study, it is important to give an insight into some of the core issues. In connection to that, I’ll explore some of the information that has been given before by other researchers   and in books which describe the behavior of consumers.   In this very portion, I shall also review some literature in line with the social and relationship marketing before moving on to establish the link between the two and behavior change. To begin with, social marketing is the process through which the strategies of marketing are applied in a systematic manner. This is always done alongside other concepts and techniques hence the main aim has always been to accomplish certain behavioral goals. The targeted behavioral goals are usually meant to achieve a specific social good. One of the major targets of social marketing is usually to promote the use of merit goods. On the other hand, it may be used to discourage people from using demerit goods. For instance, people may be advised against smoking in public areas. This can be done by outlining some of the effects of such behaviors to the members of the public There were notable early developments of this kind of strategy. For instance, in 1988, there emerged the Victoria Cancer Council in which the campaign against tobacco was stepped up. The title of the campaign which was against smoking tobacco was â€Å"quit.† Apart from that, the same institution has continued to use social marketing as a major driver in an attempt to ensure the social well being of individuals in theirs surroundings and especially at the work place. Since the advantages of social marketing were initially felt, governments have continued to apply this strategy. Many at times, they have sought to improve the process to make it more efficient. Majorly some of the improvements include the incorporation   of technology in social marketing as well as the use of social marketing and assessment response tools. The theory and practice of social marketing has therefore been embraced by many countries since its discovery in the early 1980s. some of the countries which have become profound of it include the United States, New Zealand, Australia and the U.K just to mention but a few. In line with the information above,   many a policy papers established by the government have largely adopted a special and strategic approach in publications aimed at enhancing social marketing. For instance such slogans as: choosing our health and its our health have become common phrases in such countries as England. In a nut shell, social marketing has had tremendous effects in the lives of many a people around the globe. If anything, many of those who have ever quit such addictive behaviors as smoking, while giving their testimonies have shown great appreciation to   social marketing. At the same time several rehabilitation centers seem to be getting established which shows that individuals are continuousl y responding to this strategy. The second issue which I also would like to review is the aspect of relationship marketing. In the most ancient of its definitions, relationship marketing was described as a form of marketing which is developed from marketing campaigns. The campaigns which usually solicit a direct response lays a great emphasis on customer satisfaction as well as retention. It is a strategy which therefore has less to do with dominating in the fields of sales and marketing instead, it focuses on consumer satisfaction as a major objective. This type of marketing is different from the other forms in that it concentrates more on establishing long relationships with the customer. This implies, the communication strategies do go well beyond advertisement and messages on promotion of sales. Just like social marketing, the use and application of relationship marketing has gained root in many countries and business sectors. Perhaps the major factor which has fuelled its popularity is the advancement in technology which has given birth to the use of the internet, computers, electronic billboards as well as the mobile devices. Through this,   communication which is the most effective form of establishing strong customer relationships has been widely strengthened. The strategies here involve the analysis of customer service data on top of the analysis of other demographics. The relationships also extend to marketing efforts that are inbound hence there is the use of both strategic and search optimization contents, personal relations as well as application development. One of the major theories common in relationship marketing is the theory of commitment and trust. in this description, commitment and trust are aspects which are only built when there are strong relational ties between two or more individuals. The highlighted issues are the major factors whose components I shall seek to explore in this case study. The main task here shall involve revealing the relationship between the two marketing strategies and the change in behavior of the consumers. Several theories have also been stipulated in a bid to   fully understand the behavior of individuals. For instance, Piaget, a renowned psychologist put forward various explanations in line with theory concerning the behavior of human beings. He emphasized the fact that human behavior is greatly influenced by his/her environment. This implies, the surrounding in which a person prevails goes along way in shaping the behavior of this individual. In the behavioral theory, the cognitive aspect of change in behavior has also been empasized repeatedly. In other words, the behavior of an individual is majorly a result of the interaction that he has with other aspects especially in the mind. The aspect of behavior change as a results of influence by the environment or the individuals in the environment is the main theoretical approach which shall be employed in this case study. In line with that, the study shall dig deep in order to explore how social and relationship marketing as external reinforcements affect and hence change the behavior of an individual. In the discussion above, I have given the topic a theoretical approach by reviewing some of the literature in line with the mentioned aspects. Description and justification of the method data collection of analysis. The methodological approaches which were   given to this research mainly involved the use of primary methods of research. This is because the information had to be obtained from the very individuals who had been reached by these marketing strategies. On the other hand, the information could also be obtained from the relatives and friends of the subjects. Some of the qualitative methods which were used to obtain the required data/information included the use of interviews, a series of observations and a careful analysis of certain target groups. In some case, I also employed the use of questionnaires in order to draw information form individuals at a personal level. The main strategy though was the use of interviews. The main people who were targeted by this approach included the employees of a nearby tobacco company, the managers, the city dwellers as well as the students from my school. Form the large population, I managed to pick a sample from which I intended to take my data. I interviewed a group of students from my school. A group of workers from the company and one dweller. Coincidentally, the individual had quit smoking tobacco just a year ago. After deriving some information from these individuals, I sought to reduce the size of my sample to a considerable number. From the large sample, I picked four individuals. Among the workers, I interviewed one of them who served in the marketing department. At the same time, I was able to book an appointment with the senior relationship marketing officer of the company. The third member within   my sample was a fellow school mate whose dad was an addict but the mother was under rehabilitation. Lastly, I also interviewed   my neighbor who had just retired from a cigarette firm and was also a former addict. I considered it vital to reduce the number of people to interview as this would help enhance the precision of my results. At the same time, while choosing the people, I had to consider a number of factors like their family backgrounds, the working environments or simply the surrounding in which an individual took the most of his time. The sampling method used was therefore random and judgmental sampling. I chose to use the interview as my first priority qualitative method because this approach ensures the determination of precise results. At the same time, since the interview involved a one on one, I was assured of the honesty and the willingness of the interviewees to cooperate with me through out the process. In addition to that, the qualitative method of research gave me room for comparison. For instance apart from the four, there is the portion of data that I obtained from direct observations, analysis of statistical data as well as the use of questionnaires. Through the varied sources, I was able to run across the result in order to establish consistency in the obtained data. The above information therefore gives the reasons as to why I resorted to use the above strategy. In line with the method of data analysis,   I applied the interpretation of statistical findings as well as the manipulation of the data obtained from other sources. I sampled some of the responses which were obtained through the interviews.   At the same time, I outlined some of the information which I had obtained by carrying out direct observation in line with the main subject of discussion. This I did by putting together all the   responses which seemed to adress the same aspect. In other words, all the answers which were similar were placed together. This enhanced room for comparison of data as well as determination of consistency. After a careful arrangement and interpretation of the findings, I moved on do describe my findings.   Description of findings Due to the fact that my main approach to obtaining information was through the use of interviews, I managed to obtain the first hand opinion of these individuals. In this particular section, I am going to dwell on the four individuals who I managed to interview. They included the neighbor, the schoolmate, the worker and the relationship marketing manager. My findings shall mainly be described by using quotes. The quotes in this case will include the words used by the interviewees as they responded to my questions. I really sought to know from each one of them what they could use to describe the level of social and relationship marketing today. At the same time, I requested to know if they had been reached or touched by the mentioned marketing strategies at any one point. The manager gave me such a straight response, he said â€Å" †¦.reaching people and helping them build their morals is what I dream like every second†¦..I fell in love with marketing, because some gentleman once approached me, from the way he convinced me and lured me into buying from his company., I realized there is something special with taking your time and reaching people†¦.† He continued to say â€Å" Well the marketing arena has done a lot in influencing consumer behavior, if anything, a whole bunch of the behavior of my customers has a g reat connection with how we treat them†¦Ã¢â‚¬ ¦.† From his sentiments, it was clear that social and relationship marketing both have a connection with the eventual behavior of a consumer towards a particular activity or good. According to the former employee of a tobacco firm who was my neighbor, I will denote him as Respondent-2, he said that social marketing in particular has engulfed many countries today and many a people who are addicted to smoking tobacco are because perhaps they have had limited exposure to the consequences involved. In his response he said   â€Å" I started smoking after this smartly dressed young man came up to me and described to me all the safety with doing a few puffs, he convinced me that I wouldn’t be at any risk of suffering any health complications so long as I never interfered with anyone, what I did not know was that he was luring me into being a buyer of a brand their company had just unveiled.† As the second respondent relayed his story to me, I realized that his subsequent establishment in a continuous tendency to smoke was as a result of the relationship that ensued between him and the marketing officer. He confessed of becoming a regular buyer of their cigarette brand until he got employed in his former company where he smoked for three quarters the length of the period he stayed there. According to the worker, (Respondent 3) the change in the behavior of an individual has a lot to do with the amount of influence that the surrounding and people have on this person. This implies, many a people have become more cautious with smoking while other have quit and joined rehabilitation centers mainly because the social marketing strategies caught up with them.   In line with the response of my school mate, I realized that the parents were addicts who had been introduced to smoking by a family friend who does the wholesale supply of cigars. â€Å"My dad kind off became an addict simply because the friend agreed to sell him cigars at a lower price, it is unfortunate that he even influenced mum and at times, the house becomes awful†¦.† From the above selection of just a few quotes as the interviewees responded, I was able to draw one common aspect. All the people had either been influenced to smoking or their parents or friend as a result of some sort of outreach which had been done to them. In addition to the above sample of responses on the issue of the relationship between marketing and behavior change, I was able to tally the findings and hence realized that a quarter of my schoolmates’ friends were smokers. Most of them were addicts while others were beginners. He said, â€Å"one of my classmates confessed to us that he gets paid when he manages to convince ten other people to buy from the same shop, the same brand†¦.† This implies, relationship marketing has brought the tie while the resultant behavior change is the motivation from payment and subsequent addiction. According to the relationship manager â€Å" the number of people who smoke while strictly adhering to rules against public smoking has increased tremendously, all these are fruits of social marketing.† It is important to note that I did not record every single response by the individuals above, I only sampled what I believe I’d need to draw a tacit conclusion for this case study. Comparison with literature From the discussion of the findings above, I managed to derive a number of similarities between the outcome and the data that I had initially relayed as contained in the literary materials. While giving the topic of discussion a theoretical approach, I noted that the change in behavior has a considerable amount of connection to what the environment might offer a person. In this case, the environments may include the people or the things with which we interact on a day t o day basis. A number of responses above can therefore be linked to Piaget’s theory on behavior. For instance, the mother to my schoolmate began smoking after the father influenced her, the father himself had been   influenced by the friend in a scenario which can well be termed as some form of   ‘relationship marketing’. My neighbor, the second respondent was actually introduced to smoking by a marketing officer in a meeting that was to alter his behavior for the many years that followed. He actually became a regular customer and hence smoker. This implies, the relative change in behavior was affected by what the surrounding offered just like Piaget had put it. At the same time, the manager had made an explanation in connection to the effects   of social marketing on the change in behavior of individuals. He had noted that many a people observe the health protocols and procedures on public smoking. This is a change in behavior which has since resulted from the social marketing strategies which have been stepped up. This response also tallies with the literary stipulations of the effects that social and relationship marketing has had on the behavior of individuals ever since the marketing styles came into use. According to the social marketing theory, people either stop smoking, continue smoking or do it responsibly as a result of the exposure that they have in line with the consequences.   From the findings, it is clear that the change in behavior of the interviewees who were former smokers had been affected by the amount of exposure they got in line with the effects of excessive or rather irresponsible smoking. This only emphasizes one thing that a number of external factors like marketing go along way in changing the behavior of individuals. Conclusion In conclusion, I would like to say that the change in behavior of individual towards certain things is largely affected by the type of environment in which a person dwells. For instance, staying in an environment where almost everyone smokes makes a person so vulnerable that they easily can be lured into the same behavior. Furthermore, the two marketing strategies, i.e. the social and the relationship marketing have had a considerable amount of influence on the behavior of consumers all over the world. This implies, there is a close link that exists between the behavior of individuals in the business world and amount of exposure that they get as far as social and relationship marketing is concerned. In a nut shell, from the case study   and results of the research, I was able to make a conclusion that both social and relationship marketing have great effects on the behavior of consumers. These strategies are influential hence should always be used with the main target of making the society a better place on top of boosting sales and establishing strong customer bases.

Social Networking Has Caused More Harm Than Good to People

Good day Mr. Chairman, Panel of Judges, Accurate Timekeeper, Co-debaters, Ladies and Gentlemen. I am here to support the motion that social networking has done more harm than good to Nigerian youths. Social networking has become a major part of society. Even big businesses and celebrities are jumping on the social networking bandwagon. Many people wake up each day and check social websites first thing in the morning instead of reaching for a newspaper. According to Mashable.com, as of June 2010, American Internet users spend more than 22 percent of their online time using a social networking site. Since people are spending such a large amount of time surfing social networks, it is important to point out some of the positive and negative†¦show more content†¦Connecting with others is a great way to catch up with others or to increase your career network, but allowing it to take over time you need to rest negatively affects your energy levels. Staying up late, or forcing yourself to stay up all night to socialize online, also hurts your mood and may make you short-tempered or easily angered. It also causes loss of time. If the effect of social networking means you lose time while sitting in front of the computer, you may have an addiction to social media. Spending more than an hour on a social networking site, other than for work purposes, and realizing you dont know how much time has passed is a problem. If you forget to pick up your kids from school or miss appointments because of social media, it is negatively affecting your life. Using a timer helps keep you from spending too much time online. Loss of money is also a negative effect of social networking. Many companies block social media networking sites, but those that dont often find their employees lose productivity to such sites. Using Facebook at work could lead to job loss if you miss deadlines and meetings. 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Leaders We Need Now Free Essays

The Leaders We Need Now From the Erickson’s Research article we came to learn about the three different generations of managers who tend to lead the corporate world. The baby boomers a generation who born from 1946 to 1964 have been in charge for past few decades. Boomers grew up in a world of competition where winning was very important. We will write a custom essay sample on Leaders We Need Now or any similar topic only for you Order Now The next generation was the Xers, born from 1961 to 1981. Xers were more likely to reject the traditional definitions of success and wanted to make their own way. The generation Y which came after the Xers, born from 1980 to early 2000 was also the children of baby boomers. Here we noticed that Boomers wanted to hold the position and power thinking that the Xers did not have the ability to run the business. Boomers didn’t want to retire from there work and they worked late in their life. In present competitive world we need leader who will possess the ability to build network and make strong communication throughout the business. Leader should have high experience, business-relevant knowledge, vision, decisiveness, and commanding ability. Leader must create an identity of the organization to its customers. This identity will tie its customer to the organization. Future leaders will face a complex, rapidly changing environment and problems of different types. The leader needs to compete with these challenges and seek for success from different viewpoints. The generation Xers has this type of qualities or factors. They are the potential in charge of the business world. Generation X employees will bring a new change to the leadership of corporations, because they are dissatisfied with corporate life badly. Xers are the underappreciated workforces. They are the sandwich generation between two larger cohorts: Baby Boomers and the Generation Y. And they think that they will loose management jobs because Boomers and Gen Y share a natural relationship. But if we give them the chance to lead when their time arrives, their skill, knowledge and authority roles will serve the modern corporate world effectively. Md. Shafquat Husain. How to cite Leaders We Need Now, Essay examples

Huck Finn Argumentative Essay Example For Students

Huck Finn Argumentative Essay In the book, The Adventures of Huckleberry Finn, Huck rejects sivilized life. Hedreads the rules and conformities of society such as religion, school, and anything else thatwill eventually make him civilized. He feels cramped in his new surroundings at theWidow Douglass house. He would rather be in his old rags and sugar-hogshead becausehe was free and satisfied. He felt out of place when he tried being sivilized because hegrew up fending for himself and to him it felt really lonely. Huck Finn grew up living in the woods and pretty much raised himself because hispap was a drunk. He never had a civilized lifestyle and he believed that his way of livingwas good enough for him. He was free to do what ever he liked and that is how helearned to live. He did not believe in school because all you need to know to live is notfound in a book that you read at school. He believed that you learned by living out in thewild. Huck would rather be an individual than conform to society. Huck would rather follow his heart then his head and because of this Huck is ruledas a bad person because in society your suppose to use your head. Huck is beingpenalized for his beliefs and he does not want to be apart of a lifestyle that does notsupport his ways. For instance his choice not to turn in Jim shows that Huck understandswhy Jim is escaping. Huck sees Jim as a friend not as a slave and so he truly is able to seethat societys way of treaty Jim is wrong. Huck is portrayed as a boy who sees life at facevalue and not by the set standards of the sivilized society. The rejection of the sivilized lifestyles shows that Huck does not agree with itrules. Because of this, he is able to see life from different perspectives. He cansympathize with all the class in society. He learns to figure out what is morally correctand wrong. Through out his journey down the river, Huck is able to learn more abouthimself and others. His adventures has taught him more than he will ever learn just byreading books. Huck is able to live a great life just by reacting to situations as they comealong. Huck is better off not living a sivilized lifestyle because that is how he learns. Hucks rejection of a sivilized life can be seen as being rebellious, but as youread more and more about Hucks adventures, you come to the realization that this hashelped Huck to become a well rounded person. Huck is a practical and realistic personwho grows more and more as he deals with every situation he is put in, but during histime, it was not right for a child to be on his own because they are too young to knowanything and they need guidance through school and religion. Even though Huck isyoung, he has learned a lot by reading and by self-study. Huck believes in being free so hecan able to adjust to situations rather than living a set life. Huck learns without the help ofschool and other forms that will eventually make him sivilizedand he intends to keep itthat way and therefore he runs away from the sivilized society. Huck learns from hisactions and mistakes and not from others and that is how he grows mentally andphysically. Bibliographyrunning away from sivilized society

Hyperloop Essays - Elon Musk, Business, California, Transport

Hyperloop Submitted by: Justine Mendoza, David Anton Alvarez, Hannah Tampis and Kjerstin Mijares Submitted to: Sir Migs Del Mundo Purpose and Function AHyperloopis a proposed mode ofpassengerand/orfreight transportation. A Hyperloop comprises a sealed tube or system of tubes through which a pod may travel free of air resistance or friction carrying people or objects at optimal speed and acceleration. With so little friction in the tunnel, the pods would be able to travel at immense speeds with projected top speeds of 760mph. A growing global economy requires faster, cheaper, safer and more efficient transportation modes. We haven't had a major new form of transport in 100 years, and we're due for one, especially one that is ultra-fast, on-demand, direct, emission-free, energy efficient, quiet and has a smaller footprint than other high-speed transport modes. Hyperloop is additive to existing forms of transportation and will integrate seamlessly with the transport ecosystem. It'senvironmentally friendly, with a smaller civil engineering footprint, more efficient energy consumption and no direct emissions or noise and the goal is to make it affordable for everyone. Inventor's profile Elon Reeve Musk(born June 28, 1971) is a South African -born Canadian American business magnate , investor , engineer ,and inventor . Musk is the founder, CEO , and CTO ofHYPERLINK "https://en.wikipedia.org/wiki/SpaceX" \o "SpaceX" SpaceX ; a co-founder, a Series A investor, CEO, and product architect of Tesla Inc. ; co-chairman of HYPERLINK "https://en.wikipedia.org/wiki/OpenAI" \o "OpenAI" OpenAI ; founder and CEO of HYPERLINK "https://en.wikipedia.org/wiki/Neuralink" \o "Neuralink" Neuralink . He was previously co-founder and chairman of HYPERLINK "https://en.wikipedia.org/wiki/SolarCity" \o "SolarCity" SolarCity ; co-founder of Zip2 ; and founder of X.com , which merged with HYPERLINK "https://en.wikipedia.org/wiki/Confinity" \o "Confinity" Confinity and took the name PayPal . As of July 2017, he has an estimated net worth of $16.1 billion, making him the 80th-wealthiest person in the world.In December 2016, Musk was ranked 21st on the Forbes list of The World's Most Powerful People . Musk has stated that the goals of HYPERLINK "https://en.wikipedia.org/wiki/SolarCity" \o "SolarCity" SolarCity , Tesla , and HYPERLINK "https://en.wikipedia.org/wiki/SpaceX" \o "SpaceX" SpaceX revolve around his vision to change the world and humanity . [24] His goals include reducing global warming through sustainable energy production and consumption, and reducing the "risk of human extinction " by "making life multiplanetary "by establishing a human colony on Mars . He has also envisioned a high-speed transportation system known as the HYPERLINK "https://en.wikipedia.org/wiki/Hyperloop" \o "Hyperloop" Hyperloop , and has proposed a VTOL supersonic jet aircraft with electric fan propulsion , known as the Musk electric jet . Musk also proposed the concept of The Boring Company in 2017. History Sci-fi writers and dreamers have long envisioned ways to travel at high speeds through low-pressure tubes. Robert Gaddard , rocketry pioneer, in 1909 proposed a vacuum train very similar in concept to Hyperloop . In 1972, the RAND Corp. conceived a supersonic underground railway called the Vactrain . Travelling together on a humanitarian mission to Cuba, venture investor and entrepreneur Shervin Pishevar and Elon Musk get to talking about Musk's idea for the Hyperloop , an update on the idea of moving vehicles at high speeds through low-pressure tubes. A few months later at a tech conference Shervin urges Musk to share his ideas with the public. On August 2013, Elon Musk publishes the Hyperloop Alpha white paper which incites overwhelming industry excitement. Shervin presents it to President Obama , whose science advisors say it's feasible.

20 Analytical Essay Topics Urban Economics Points to Use While Writing

20 Analytical Essay Topics Urban Economics Points to Use While Writing If you are tasked with writing a great analytical essay on the topic of urban economics, then you should start off on a great foot by reviewing the potential twenty topics listed below. See if any of these fits within the parameters of your writing assignment and let the creativity flow: The Key Economic Forces Which Drive The Creation and Support of Cities as well as Regional Agglomeration The Theory and Evidence Which Supports the Emergence of Cities Why Location of Workers and Firms is the Part of Core Periphery Model of Urban Economics The Impact That the Emergence of Cities Has on Worker’s Productivity How Manufactured Goods Are Contingent upon Economies of Scale with Amount of Production Limited by Returns The Impact That the Emergence of Cities Has on Urban Amenities How Agricultural Products Rely on Unskilled Labor and Have Set Products Produced at a Rate Constant with the Scale, Reliant upon a Fixed Designation of Land and a Fixed Designation of Unskilled Labor in order to Produce Said Products The Impact That the Emergence of Cities Has On Congestion How the Price for Modern Products is Related to Trade Cost as well as Competition Cost How Imported Products are Priced Higher because of Regional Differences Why Higher Import Costs Result in Lower Local Consumption and Higher Consumption of Non-Imported, Local Items The Symmetric Equilibrium for Symmetric Regions and How Firms Remaining in Their Region Maintain This Equilibrium The Self-Correcting Swap Model for Relocation The Self-Reinforcing Relocation Model The Issues in Measuring Urban Characteristics The Methodologies Used in Measuring Urban Characteristics The Designing of the Most Appropriate Urban Policies Economic Theory and Evidence to Support the Internal City Structures Economic Theory Supporting Urban and Housing Policies, Specifically How They Enhance Urban Living Environments The Role Cities Play in the Development of Aggregate Economics To write a better analytical essay on urban economics, you must surely go through the facts on urban economics together with the writing guide. Of course, writing a good analytical essay about urban economics requires more than just selecting the topic, flicking through some facts, which is why you will find a sample essay below on one of the topics listed above: Analytical Sample Essay: Why Location of Workers and Firms is Part of Core Periphery Model of Urban Economics Urban economics is a vast field whose theories dictate that the location of workers and their firms is directly related to the production of products, competition, costs, and the growth of cities. In theory equilibrium is achieved among all manufacturing firms when each location maintains equal footing in various regions. If there are two distinct regions, the West region and the East region, there could exist three companies manufacturing different product varieties in both the East and the West regions. So long as each company maintains production in a specific region with limited imports into the opposite region, equilibrium can be achieved. The reason for this is that the same employment opportunities exist in both regions for all potential workers. Because of the similar demand and the similar supply the wages available for employees also remains roughly even. When companies in the East want to supply products to the west, they have to pay for transportation costs which are refe rred to as the trade costs. In supplying products to the east to be imported the Western manufacturers have to increase the price of their products to cover the trade cost. If an increase in price for imported products took place, many consumers would purchase if you imported products in exchange for higher numbers of local products. That being said companies in the East can produce local products and consumers will buy imported products from the west at a smaller rate compared to the products that they purchase from local suppliers in the east. With this in mind cities do not grow exponentially, urban landscapes remain roughly the same, and all businesses have the ability to compete within the open market at regular competitive prices and demand , forcing them to focus instead on simply providing a unique variety to similar products. This can be changed when a single manufacturer from the West decide to move the firm, relocating it to the east. When the relocation from the west to the east takes place, production changes, trade cost goes away and demand changes too. When the trade cost goes away consumers are more likely to purchase products from the newly relocated Western company now situated inside of the eastern region. In some cases this will naturally balance out, reverting back to the equilibrium which once existed by way of a similar manufacturing firm located in the east simply moving their production to the west. By doing this the two companies switch places and maintain the same products, profits, and consumer base demand. Of course the alternative to this is that the increased profits now gained by the Western company that recently moved to the eastern region serve as a tantalizing suggestion or opportunity for the other company remaining in the West. As such additional companies in the West can reloc ate to the east, essentially taking all profits away from those local eastern based manufacturers. When things like this take place changes in demographics, larger city development, and grand changes to the economic landscape are inevitable. Again a potential change to this can be the natural swap of the aforementioned companies from the east simply assuming the open opportunity now left in the West. In all cases this serves as a prime example of how production and location influence city development and are imperative to the understanding of urban economics and development. Overall fluctuation in the economic landscape can impact the development of cities, and by extension can impact the development of urban policies and land planning as well as urban living policies. As companies grow and changes take place in the existing workforce, manufacturing landscape, and product availability, subsequent changes have to take place in terms of policy and workers, wages, and products. References Alonso, William.  A Model Of The Urban Land Market. 1960. Print. Arnott, Richard, and Daniel P McMillen.  A Companion To Urban Economics. Malden, MA: Blackwell Pub., 2006. Print. Harvey, J, and Ernie Jowsey.  Urban Land Economics. Basingstoke: Palgrave Macmillan, 2004. Print. OSullivan, Arthur.  Urban Economics. Boston: McGraw-Hill/Irwin, 2003. Print. Perloff, Harvey S, and Lowdon Wingo.  Issues In Urban Economics. [Baltimore]: Published for Resources for the Future [Washington] by the Johns Hopkins Press, 1968. Print. Rasmussen, David W.  Urban Economics. New York: Harper Row, 1973. Print. Segal, David.  Urban Economics. Homewood, Ill.: R.D. Irwin, 1977. Print.

Critical thinking Essay Example | Topics and Well Written Essays - 750 words

Critical thinking - Essay Example The relationship between education and gender during eighteenth, nineteenth and twentieth centuries is also explored by the author. The paper also demonstrates rejection that women faced in the early days. They were rejected by their male counterparts as seen in Cambridge University. Gender issues as embedded in social structures have dramatic impacts on access of knowledge by women. The paper uncovers array of neglected issues affecting hierarchical social structures. Furthermore, the article indicates that women are capable of learning and accessing all forms of knowledge just as men can. The discussion below portrays factors that limited the accessibility of relevant education by women around the world. In addition, the discussion reveals some radical developments that have occurred over time which have opened up opportunities for women to explore and exploit their abilities and talents. Intellectual development has been a very long and tedious process among women in the world. During eighteenth century, women were not allowed to learn scientific subjects as their male counterparts. Mind development was regarded as unimportant to women. They were allowed to access moral and religious teachings but not scientific ones. Religious precepts did not entail elite languages which were allowed for men. Conversations on chemistry during late eighteenth century reveal excitement of discovery and new knowledge amongst women in the world. Adoption of conversations and experiments by Marcet indicates progress in knowledge development which was not expected of girls hence it limited their ability to display their unique understanding of concepts. In the early eighteenth century, scientific ideas, as revealed by the case of Aristotle, show the opposition that women based in discovery of scientific ideas faced. Philosophies were associated with men and superiority in which

Opening the West to New Horizons Essay Example | Topics and Well Written Essays - 2000 words - 1

Opening the West to New Horizons - Essay Example To receive a better understanding of the difference between Carl and David, it is essential to go through and compare the two geographers and their way of thinking. Carl was a more open minded sort who felt as if cultures should be respected and studied in depth to understand how various people used their surroundings to flesh themselves out. He believed that past societies developed their cultures according to what was available to them. Take for instance a culture built near an ocean. Carl would believe that most certainly the ocean and seafaring would certainly play roles in the development of the societies religion and moral codes. Water could be considered sacred to such a society. Then there is the other end of the spectrum, where David Livingstone comes in. Although he still respected many other cultures, he almost felt they were inferior to the modern ideals of Christianity. He believed that through Christ, many cultures across the world could open themselves to Western culture and commerce, and that it would benefit them more than their own cultures. He felt a need to spread the word of God to these various other societies without regarding their own cultures as nearly important as the will of God. He believed that no matter what conditions the society was in, by following God and Christ, they could reform and better themselves in every aspect of life, no matter what, and made it his lifes mission to accomplish this.

Evaluate how the NATIONAL GRID TRANSCO applies the expectation and Essay

Evaluate how the NATIONAL GRID TRANSCO applies the expectation and requirements of corporate governance - Essay Example This framework even encompasses procedures and rules which are undertaken while framing corporate affair decision. It highlights the process by means of which are objectives are set and achieved in terms of market, social and regulatory environment. Governance mechanism takes into consideration different elements such as monitoring decisions, actions and policies of agents as well as corporations. On basis of this framework, actions undertaken by management are closely monitored in order to eliminate any form of agency risks. However contemporary interest of this concept is related to mitigating conflicting interests amongst stakeholders. There are various approaches implemented to prevent such conflicts such as well defined processes, institutions, laws, policies and customs. An important component of corporate governance is extent and nature of corporate accountability. In this study corporate governance framework of a particular firm will be thoroughly analyzed known as National G rid Transco. It is a multinational company of electricity and gas utility, and has its headquarters in London. The firm has its principal operations in North-eastern United States and United Kingdom. National Grid Plc., was founded in 1990 and in current decade has a market capitalization of  £31.4 billion. The company has gone through a series of mergers and acquisitions but the most important merger took place in 2002 where Transco’s owner Lattice Group Plc., merged with National Grid Group. This in turn resulted into a new organization which came to be known as National Grid Transco Plc. In this study corporate governance expectations will be analyzed on the basis of practices undertaken by National Grid Transco. There are different theoretical frameworks related to corporate governance but some amongst them holds great deal of significance in modern era. Finance or principal-agent model is a well known corporate

Inborn errors of metabolism

Inborn errors of metabolism 1.0 Abstract Inborn errors of metabolism occurs 1 in 5000 births collectively. They can be treated if the inborn error is diagnosed properly and early. They are manly caused by a gene defect that blocks vital metabolic pathways. The can be server, which is mainly due to amount of enzymes that is causing the block or deficiency of the reaction product. This can affect the organs and also have local effect such as lysosomal storage disease. The symptoms can vary, from mild to severe. They affect any organs and occur at any time. To recognise the Inborn Errors of Metabolism, the doctor must be suspicious; for example a baby that show signs of antecedent maternal fever should undergo a blood culture and also undergo simple tests such as Amino acids, Organic acids, Glucose, Electrolytes, Lactate, and Ammonia; which is done in the laboratory. 2.0 Abstract Inborn errors of metabolism (IEM) are a group of genetic disorders that are rare. These disorders are genetic diseases that are involved in metabolism disorders. A large section of these disorders arise from single genes that encodes for enzymes; that have been defective. These enzymes are important that they catalyses chemical reactions converting substrates to products essential for everyday living. Inborn errors of metabolism disorders can arise from a number of conditions such as prolong exposure and accumulation of substances which are toxic, and the interference of normal functions and the inability to produce and synthesize essential compounds. Inborn errors of metabolism has related to defects in or damage to a developing foetus that may have been caused to genetic changes, that is why Inborn errors of metabolism is sometimes referred as congenital metabolic diseases. Inborn errors of metabolism have also been linked to heritable disorders within biochemistry, for example phe nylketonuria (PKU). That is why some times it is referred as inherited metabolic diseases as well. In the perspective of changes of normal mechanical, physical, and biochemical functions, IEM can divided into three useful groups that can be analysed diagnostically. Group 1: Disorders which causes intoxication. Group 2: Disorders involving energy metabolism. And Group 3: Disorders involving complex molecules. 1.0 Introduction 1.1 Inborn Errors of Metabolism In the early 1900s, a researcher called Sir Archibald Garrods based his studies on genetic metabolic disorders and discovered IEM [1, 2]. He was known for his work on the one gene, one enzyme hypothesis, based on his studies on the nature and inheritance of alkaptonuria. And gave the name and wrote a book on IEM (The Incidence of Alkaptonuria: a Study in Chemical Individuality.) [1, 2]. IEM can arise from a number of causes, but the major cause is alteration of a specific metabolic reaction [1, 2]. IEM has been shown to develop at a very young age, where epidemiology findings indicated that hundreds of IEM affects about 1 in every 5000 born babies [2]. But as technology advances and improved techniques such as metabolomics, has been easy to develop newborn screening that improves early diagnosis and treatment in a number of IEM disorders [2]. But as these new techniques cost a lot to run and time increases, proving to be unreliable [2]. The study and the knowledge about inborn errors of metabolism (IEM) have improved due to the latest advancement in technology and techniques [2, 3]. These improvement have led us to the conclusion, for example urea cycle disorders and organic acidemias may and will lead to the accumulation of ammonia, which is a toxic product of amino acid metabolism [2, 3]. Also the latest findings are that inborn errors of metabolism (IEM) may impair brain function due to defects in the mitochondrial respiratory chain and disorders in gluconeogenesis [4]. There are 10 facts that need to take inconsideration when people with IEM undergo clinical diagnosis [5]. Common condition such as, intoxication, encephalitis and brain tumours in older patients and also sepsis have to be analysed properly and always consider IEM in the same field [5]. Symptom that persists and that are unexplained even before, during and after initial treatment and usual investigations has been performed, have to be taken to consideration that it could be IEM [5]. Newborn babies that have organ dysfunction, hypo-perfusion, or hypotension can develop sepsis, which can be caused by IEM. So any babies in neonatal intensive care unit that die, the first cause that has to be taken to account is IEM [5]. Have to take extra care in reviewing all autopsy findings [5]. The examiner must not confuse a symptom for example peripheral neuropathy; or syndrome such as sudden infant death with etiology [5]. IEM can develop and present at any age, for example from foetal life to old age [5]. The examiner must take to account that not all genetic metabolic errors causes are due to hereditary and transmitted recessive disorders, but a large section of individual cases are sporadic [5]. Always consider inborn errors of metabolism are open to treatment for example with patients that have inborn errors of metabolism due to intoxication [5]. In server situations, the examiner will need to take a few patients with IEM that are able to diagnose and treat the patient with IEM [5]. The examiner must be open to obtain help from specialised centres that specialise with IEM [5]. The metabolic disorders can be set into three useful groups that can easily be distinguished from each other [5, 6, 7]. These three groups are sorted from a pathophysiological point of view [5, 6, 7]. The groups are; Group 1: Disorders which is caused by intoxication [5, 6, 7]. Group 2: Disorders involving energy metabolism [5, 6, 7]. And Group 3: Disorders involving complex molecules [5, 6, 7]. 1.2 Group 1- Disorders which is caused by intoxication In this group, it describes inborn errors of intermediary metabolism. These inborn errors cause acute of progressive intoxication from long exposure and increase of toxic compounds, forming a metabolic block [5, 6, 7]. In group 1 the inborn errors are manly amino acid catabolism [5, 6, 7]. These include phenylketonuria, where there is a deficiency in the enzyme phenylalanine hydroxylase (PAH); which is needed to metabolise the amino acid phenylalanine to the amino acid tyrosine [5, 6, 7]. Homocystinuria is an inherited disorder of the metabolism of methionine [5, 6, 7]. Tyrosinemia is where body cannot break down the amino acid tyrosine [5, 6, 7]. Also organic acidurias such as methylmalonic acidemia, and propionic acidemia [5, 6, 7]. Sugar intolerances are also classified in group 1 [5, 6, 7]. These include hereditary fructose intolerance caused by a deficiency of liver enzymes that metabolise fructose. Metal toxication also falls under group 1; such as hemochromatosis, where the patient has accumulated a lot of iron [5, 6, 7]. All these metabolic disorders have something in common, in that they do not affect the embryo development, and also show similar symptoms of clinical intoxication [5, 6, 7]. A patient with group 1 disorders may show an acute signs of vomiting, coma and liver failure; or chronic signs which are cardiomyopathy, developmental delay and failure to thrive. Acute symptoms that can worsen are catabolism, fever, and food intake [5, 6, 7]. The analysis in group 1 is easy, and without any complications [5, 6, 7]. It needs the use of chromatography in which the plasma and urine amino acid. Most of group 1 disorders are treatable. Treatment is usually involves special diets and cleansing drugs such as sodium benzoate and penicillamine, to remove the toxins [5, 6, 7]. The inborn error of amino acid synthesis is also included to this group, as they have the same or similar features [7, 8]. They are inborn errors of intermediary metabolism; the analysis requires the plasma and urine where disorders are able to be treated even when the disorder starts with in the uterus, for example 3-phosphoglycerate dehydrogenase deficiency [5, 6, 7, 8]. 1.3 Group 2- Disorders involving energy metabolism In this group inborn errors are errors of intermediary metabolism as well. The symptoms are mainly caused by a lack of energy production or utilization. This will involve the liver, myocardium, muscle, and brain [5, 6, 7]. There are two types of disorders involving energy metabolism. 1. involves mitochondrial energy defects. 2. involves cytoplasmic energy defects [5, 6, 7]. Mitochondrial energy defects are more aggressive and are not fully treatable [5, 6, 7]. Mitochondrial energy defects cause lactic acidemias where there is dextrorotatory lactic acid in the circulating blood, resulting to defects of the pyruvate transporter resulting to PKU, pyruvate carboxylase this causes lactic acid to accumulate in the blood, pyruvate dehydrogenase where the patient can show symptoms of severe lethargy, and defects in the Krebs cycle [5, 6, 7]. But some defects such as fatty acid oxidation and ketone body defects are partly treatable [5, 6, 7]. Cytoplasmic energy defects are not as much aggressive then mitochondrial energy defects. A cytoplasmic energy defect causes disorders of glycolysis, glycogen metabolism and gluconeogenesis [5, 6, 7]. And recent study showed it causes disorders of creatine metabolism which it is partly treatable by oral creatine supplementation [5, 6, 7]. Cytoplasmic energy defects can cause disorders that are untreatable, such as errors of the pentose phosphate pathway which will be described in further details [5, 6, 7]. In group 2, the common symptoms are heart muscle disease, hypoglycaemia, myopathy which is a muscular disease, cardiac failure, specific failure of the circulation, sudden death especially in infancy [5, 6, 7]. Mitochondrial disorders and as well as the pentose phosphate pathway defects can obstruct embryo-foetal development and give rise to dysmorphism, dysplasia causing an abnormality in maturation of cells within a tissue and congenital disorder [5, 6, 7, 9]. The analysis and the diagnosis are hard to put through as it requires 4 different tests [5, 6, 7]. 1. Function tests [5, 6, 7]. 2. Enzymatic analyses needing biopsies [5, 6, 7]. 3. Cell culture [5, 6, 7]. 4. Molecular analyses [5, 6, 7]. 1.4 Group 3- Disorders involving complex molecules. Group 3 involves cellular organelles [5, 6, 7]. The diseases that fall under group 3 modify the synthesis or the catabolism of complex molecules [5, 6, 7]. There are symptoms that are permanent and progressive, and some symptoms free from intercurrent events [5, 6, 7]. In this group there are disorders such as lysosomal storage disorders, peroxisomal disorders and inborn errors of cholesterol synthesis etc. In this group treatment is difficult would need enzyme replacement therapy, especially for lysosomal disorders [5, 6, 7, 10]. 2.0 General Symptoms and Signs There is a way for testing newborn babies for inborn errors [11]. This process is called Newborn screening. This tests babies at a very early age for four types of diseases that are treatable: genetic, endocrinologic, metabolic and hematologic diseases [11]. Dr Robert Guthrie was a microbiologist who designed a dried blood spot testing, and used it to screen for phenylketonuria [12]. To this present day that spotting test is still being used. As techniques have improved so have the screening [12]. A physician who is screening a newborn baby for a metabolic disorder has follow four groups of clinical circumstances: The physician must find early symptoms, especially in the antenatal and neonatal period of development. In the later stages the physician must find symptoms that are server and recurring. Symptoms such as coma and vomiting. If the physician finds any symptoms that are chronic and aggressive, they could be due to three things: 1) Gastrointestinal. 2) Muscular. 3) Neurological. These will be described in more detail below The physician must find any signs of cardiomyopathy, hepatomegaly etc. This could lead to organ failures. The three groups have symptoms that are chronic and aggressive that can be easily ignored or misinterpreted. 2.1 Gastrointestinal Symptoms. If a patient has inborn errors of metabolism (IEM), the person might have symptoms that fall under the Gastrointestinal Symptoms (GI) group [13]. These symptoms include Anorexia, which is an eating disorder [5, 13]. Osteoporosis which untreated could lead to bones fracturing. Chronic vomiting, feeding difficulties, and failure to thrive are also symptoms of (GI). But they are also associated with chronic diarrhoea [5, 13]. This could lead to false and the wrong diagnosis [5, 13]. There are two groups that have been described to have caused chronic diarrhoea and failure to thrive within inborn errors of metabolism: These disorders include errors of the intestinal mucosa or the exocrine function of the pancreas, for example congenital chloride diarrhoea, glucose- galactose malabsorption a condition in which the cells lining the intestine cannot take in the sugars. Lactase and sucrose-isomaltase deficiencies where the person is unable to metabolise lactose or sucrose. Abetalipoproteinemia type II disorder that interferes with the normal absorption of fat and fat-soluble vitamins from food [5, 13]. Enterokinase deficiency; Enterokinase is an enzyme involved in human digestion. Acrodermatitis enteropathica, a condition that affects that absorption of Zinc. Etc [5, 13]. Systemic disorders such as diabetes mellitus, diabetes, sickle cell disease, sarcoidosis, etc can also give rise to GI abnormalities. A problem has risen in distinguishing systemic abnormalities and inborn error of metabolism and vice versa [5, 13]. 2.2 Muscle Symptoms. There are a number of symptoms that fall under this group. For example: Hypotonia, where there is a disorder that causes low muscle tone and strength [5, 14]. Muscular weakness and poor muscle mass [5, 14]. These symptoms are common with many inborn errors of metabolism. These symptoms can be caused by urea cycle defects and many amino acid metabolism disorders [5, 14]. Recent studies have shown that the cause of muscle symptoms can be due to mutations in the monocarboxylate transporter 8 gene, which can develop Allan-Herndon-Dudley syndrome [14]. Allan-Herndon-Dudley syndrome falls under the muscle symptoms group as it causes hypotonia, general weakness of the muscle, reduced muscle mass and delayed development [14]. Further studies showed that this X-linked mental retardation syndrome is involved in the transport of triiodothyronine into neurones and disrupts the blood levels of thyroid hormone [14]. 2.3 Neurological Symptoms. Patients with inborn errors often have neurological symptoms. These include of neurological abnormalities, in the central and peripheral system. Studies have shown that these neurological symptoms are very frequent with inborn errors [5, 15]. These symptoms include poor feeding, hypotonia, ataxia, and even autistic features [5, 15]. The analysis of inborn errors, due to the screening of neurological symptoms is very difficult due to symptoms that are non specific signs; sings that include for example developmental delay, and hypotonia [15]. 3.0 Screening Newborns for Inborn Error of Metabolism 3.1 Newborn screening Newborn screening is a technique, used to detect inborn errors [17, 12]. It was first used to detect phenylketonuria (PKU) by a bacterial inhibition assay, developed in the 1961 by Dr Robert Guthrie as already stated. His technique in using dried blood sample was further developed in the mid 1975, where a scientist called Dussault used a method to screening for congenital hypothyroidism [16]. A lot of time and money has been invested into the screening programme, and now they have uncovered new disorders that are related to inborn errors [17, 12]. Disorders such as cystic fibrosis, congenital adrenal hyperplasia, which is a form mutation of genes that produces enzymes that mediating production of cortisol from cholesterol by the adrenal glands. Glucose-6-phosphate dehydrogenase deficiency and many more [5]. To this present day, for screening newborns, tandem mass spectrometry is used [18]. It is a lot easier for screening and diagnosis. The application of tandem mass spectrometry to newborn screening was first described in 1990 [18]. The primary aim of newborn screening is to identify patients, manly infants with serious disorders that are treatable [18]. This will make it easy to prevent or improve clinical symptoms of the disease [18]. Tandem mass-spectrometry is very useful in detecting more than one disorder at one time [18]. This can be used to detect early untreatable disorders and also can be beneficial if the screening was not limited to just individual babies, but the whole family as well [18]. The screening process uses MSMS [18]. MSMS is the method used to measure analytes by both mass and structure [18]. First the compounds are ionised, where the first mass spectrometer selects the ion of interest, where it is sorted by weight [18]. Then the compounds travel through a collision cell, are dissociated to signature fragments, and then pass into a second mass spectrometer where ions are selected for detection. [18]. 3.2 Method for screening Research have been done where most newborn screening programmes use simplifying sample preparation, instead derivatisation of the sample which is the old method [18]. When investigating, the sample might show more than one disorder. But the use of ratio of analytes improves sensitivity and specificity [19]. Specialised biochemical genetic testing is always done to verify which type of disorder the patient has [18]. Theses genetic tests include amino acid analysis, organic acid analysis by gas chromatography/mass spectrometry, and plasma acylcarnitine profile by MSMS [18]. 4.0 Screening for Individual Inborn Errors of Metabolism Well over 40 inborn errors of metabolism can now be detected by newborn screening [20]. This section will look at three inborn errors. 4.1 Pentose Phosphate Pathway The pentose phosphate pathway (PPP) is an anabolic pathway where is uses a 6 carbon glucose to generate a 5 carbon sugars and reducing equivalents, as shown in Fig. 1. There are three primary functions of this pathway [21]: To generate reducing equivalents, such as NADP forming NADPH. NADPH allows reduction biosynthesis reactions to occur within cells [21]. To produce ribose-5-phosphate (R5P) for the cell, for the synthesis of the nucleotides and nucleic acids [21]. Can metabolise dietary pentose sugars that are derived from digestion of nucleic acids [21]. These also rearrange the carbon skeletons of dietary carbohydrates into glycolytic/gluconeogenic intermediates [21]. 4.1.1 Disorders of the Pentose Phosphate Pathway There are three inborn error in the pentose phosphate pathway that have been identified [21]. 4.1.2 Glucose-6-phosphate dehydrogenase deficiency The enzyme glucose-6-phosphate dehydrogenase (G6PDH), catalyses the reaction that converts glucose-6-phosphate to 6-phosphogluconate. This creates one mole of NADPH each for every mole of glucose-6-phosphate (G6P) that enters the PPP [21]. A deficiency would lead to an error to the first irreversible step of the pathway [21]. This would lead further to a lower production in NADPH, making the cell more acceptable to oxidative stress [21]. G6PDH is very important for Erythrocytes metabolism [21]. A deficiency could lead Individuals to nonimmune hemolytic anaemia which can be caused by, infection or exposure to certain medications or chemicals [21]. G6PDH deficiency is also linked to favism [21]. It is thought to be an X-linked recessive hereditary disease [21]. 4.1.3 Ribose-5-Phosphate Isomerase Deficiency A recent study have shown that a patient with of ribose-5-phosphate isomerise deficiency, had developed progressive leucoencephalopathy and, developmental and speech delay [21]. They did further studies using NMR and found that polyols ribitol and D-arabitol concentration was abnormal in body fluids [21, 22]. They did their studies on fibroblasts and found that the enzyme gene-sequence analysis showed a frame-shift and a missense mutation [22]. 4.1.31 Metabolic Derangement Ribose-5-phosphate isomerase deficiency would mean that the reversible reaction converting ribose-5-phosphate to ribulose-5-phosphate and vice versa will halt [22]. If there was no deficiency ribulose-5-phosphate would be converted to xylulose 5-phosphate, which will provide the substrates for transketolase and further conversion into glycolytic intermediates [22]. Studies have found that there are two mutant allele one from each parents that results in ribose-5-phosphate isomerise gene that causes the deficiency [22]. So it could be an autosomal recessive inheritance disorder [22]. The best way to do a diagnostic test for Ribose-5-phosphate isomerase deficiency would be to take a urine sample [22]. Polyols ribitol and D-arabitol would be analysed [22]. Also enzyme assay can be used to sequence the ribose-5-phosphate isomerise gene [22]. 4.1.4 Transaldolase Deficiency Some studies have been done where three unrelated families had Transaldolase deficiency [23]. One patient had aortic coarctation where the aorta narrows [23]. During the patients life they found that ammonia was rising. But neurological and intellectual development has been normal. Another patient had HELLP syndrome (hemolysis, elevated liver enzymes and low platelet count) [23, 24]. Children with transaldolase deficiency have been diagnosed have found that the development of intellectual and neurological showed no abnormalities [23, 24]. But there is a strong link to liver cirrhosis which results from increased cell death of hepatocytes and biliary epithelial cells [23, 24]. 4.1.41 Metabolic Derangement Transaldolase catalyses the reaction: Sedoheptulose 7-phosphate + glyceraldehyde 3-phosphate erythrose 4-phosphate + fructose 6-phosphate [59]. It is a reversible reaction in the pentose phosphate pathway. The deficiency lead to the accumulation of polyols derived from the pathway intermediates: erythritol, arabitol and ribitol [59]. Studies have shown that all patients were homozygous for these specific mutations, suggesting autosomal recessive inheritance [23, 24]. A simple urine test can be done to diagnose of transaldolase deficiency, mainly because there is a high concentration of arabitol and ribitol in urine. Also enzyme assay can be used to sequence the gene [23, 24]. Liver transplant would be the only option with patients that have severe liver cirrhosis [23, 24]. 4.2.0 Insulin secretion by the pancreatic ß-cell In the production of insulin glucose enters the ß-cell through a GLUT2 transporter where it is phosphorylated to glucose-6-phosphate by the enzyme glucokinase [58]. The enzyme is used as a control, where it monitors the level of glucose [58]. As blood glucose raises the rate of glucose metabolism also increases, where the cell will undergo glycolysis generating ATP [58]. This increase of ATP concentration causes K+ channels to close, making the membrane depolarised [58]. This depolarisation causes the voltage sensitive Ca2+ channels to open and Ca ions flood in, stimulating insulin secretion by exocytosis from storage granules; this is shown in Fig. 2. 4.2.1Persistent Hyperinsulinemic Hypoglycaemia Hyperinsulinism has been diagnoses in all ages but it is very common in childhood [25]. Persistent hyperinsulinemic hypoglycaemia (PHHI) is the one of the main cause of hypoglycaemia especially in young children. Patients who are older, that develop PHHI are due to pancreatic adenoma [25]. Hypoglycaemia when there is an overproduction of insulin by the ß-cells in the pancreas [25]. Hypoglycaemia can produce a variety of symptoms the most dangerous is brain damage which can lead to death, and that is why treatment is vital [25]. PHHI has two histopathological lesions that can be easily distinguished, making PHHI a heterogeneous disorder [25]. Focal hyperinsulinemic hypoglycaemia (FoPHHI) is caused by loss of heterozygosity which is a somatic event [25]. This causes focal adenomatous hyperplasia, which is a pancreatic lesion [25]. They are treated with pancreatectomy, where they surgically remove part of the pancreas. Diffuse hyperinsulinemic hypoglycaemia (DiPHHI) is also a heterogeneous disorder, in that fact that it is unable to encode for proteins needed for insulin secretion [25]. This can also be caused autosomal recessive and dominant genes which are rare [25]. Positron emission tomography (PET) is used to distinguish between focal and diffuse PHHI [25]. This gives a 3D image or picture of functional processes in the body [25]. Once a patient is diagnosed with PHHI, they are on treatment straight away with glucose and glucagon [25]. 4.2.12Metabolic Derangement Hyperinsulinemic hypoglycaemia is due to insulin hypersecretion by the pancreas [25]. The Action insulin causes a decrease in plasma glucose by inhibiting hepatic glucose release from glycogen and gluconeogenesis, and by increasing glucose uptake in muscle and fat [25]. PHHI is a disorder that is caused by a variety of defects, either in regulation of insulin secretion, unable to transcribe the enzymes needed of even a modified receptor [26]. For example diseases that can affect the ion channels like seizures [27, 28, 29]. Also lack of enzyme production of glucokinase (GK), and glutamate dehydrogenase (GDH) [30, 31]. Epidemiology has found that 1/50,000 patients are born with PHHI [32, 33]. Focal hyperinsulinemic hypoglycaemia is strongly linked to mutation of the sulfonylurea-receptor and the K+ channels, both used to depolarise the cell [32, 33]. Both are found to be located on the chromosome 11p15 [32, 33]. To identify these mutations they would need to be tested in a foetus or embryo before it is born. Sulfonylurea-receptor gene (SUR1) will not respond to diazoxide, which is used as a K+ channels activator [34]. Studies have found that a high activity of the enzyme glutamate dehydrogenase (GDH) has resulted to hyperinsulism/hyperammonemia syndrome. This would make sense as GDH is needed to produce insulin and this would impair detoxification of ammonia in the liver [31]. The enzyme glucokinase (GK) is also expressed highly, where the affinity is increased for glucose, causing high levels of insulin secretion [30]. 4.2.13 Diagnostic Tests Diagnostic of HI is easy, in the fact that, it can be indicated by the levels of glucose in the blood. Treatment varies from age [35]. Hyperammonemia should be treated as another disease, when a patient has PHHI, when treating hyperinsulism/hyperammonemia syndrome. This can be done by analysis of urine organic acids and plasma acylcarnitines [36]. Patients who show the FoPHHI can have lesion ranging from 2.5 to 7.5 mm in diameter [37, 38]. People who have DiPHHI found that there was ß-cells that were abnormal [39]. Pancreatic venous catheterization (PVS) and pancreatic arteriography have proven very useful in locating the site of insulin secretion [40, 41]. PVS procedure will have to able to maintain blood glucose level, which is between 2 and 3 mmol/l. Blood sample would then be taken from the pancreas to measure 3 things 1.plasma glucose, 2.insulin and 3.C-peptide levels [40, 41]. Studies have shown that people with FoPHHI tend to have high concentration of plasma insulin and C-peptide levels in some samples and low concentration in others [40, 41]. People who have DiPHHI tend to find that all their sample have high concentration of plasma insulin and C-peptide [40, 41]. The use of [18F]-labelled fluoro-L-DOPA whole-body positron emission tomography (PET), has proved to be very useful in detecting hyperfunctional islet pancreatic tissue, where this can be used on patients with focal lesion [42]. Recent studies have shown that a new technique have been use to locate focal lesion and separate focal from diffuse forms of HI; this is the tolbutamide test [44, 45]. 4.2.14 Treatment and Prognosis Brain damage can occur if you are hypoglycaemic, so treatment needs to be quick. Glucagon would be given, where the patient would have to take 1 to 2 mg per day if blood glucose levels are unstable [35]. To treat PHHI, diazoxide would be given, usually at a dose of 15-10 mg/kg/day depending on your age [35]. Normal blood glucose levels should be between 4 and 7 mmol/l, before and after a meal [56]. This could need to be check every time once taking diazoxide [35, 56]. Octreotide treatment, can also be used as it is a hormone inhibitor [46]. But a high could lead to a more severe hypoglycaemia, as it can inhibit glucagon and growth hormone [46]. Patients will find that after treatment with octreotide, they might vomit or have diarrhoea [46]. Calcium-channel blockers could be used, such as Lercanidipine and Pranidipine [46]. These treatments that have been mentioned are very effective in controlling blood sugar [46]. If a patient is diagnosed with FoPHHI, the treatment tends to be surgical as drugs are ineffective [46]. They would undergo pancreatectomy. This procedure has its risk as the patient might develop diabetes mellitus [46]. DiPHHI patients have been found to have large nuclei in the ß-cells [35, 47]. And patients with FoPHHI showed no abnormal s-cell nuclei but did show shrunken cytoplasm [49, 50]. 4.3 Glucose Transporter Deficiency Monosaccharides such as glucose and fructose have the properties of being hydrophilic [59]. The lipid bilayer has hydrophilic heads and hydrophobic tails, prevent polar molecule such as glucose from diffusing across the membrane [59, 60]. So transport mechanisms are needed. These are hydrophilic pores allowing polar molecules to diffuse in and out of the cell [59, 60]. There are two types of glucose transporters. 1. Sodium-dependent glucose transporters (SGLT), which have been found to be located in the small intestine and the proximal tubule [59, 60]. SGLT uses the difference in concentration of sodium to transport glucose [59, 60]. From high to low concentration of sodium causes the transport of glucose against its own concentration gradient [59, 60]. 2. Facilitative glucose transporters (GLUT), which has been found throughout the body, but manly in muscle and pancreas cells [59, 60]. These transporters transport glucose from high to low concentration [59, 60]. Studies have shown that there are four defects in the transport of monosaccharides [59, 60]. These defects can depend on where the transporters are located within the body and what they transport in and out of the cell [59, 60]. As already stated there are four defects. 1. SGLT2, which is found in renal tubulus cells that can cause renal glucosuria [59, 60]. 2. SGLT1, which is found in the intestine, which can cause glucose-galactose malabsorption [59, 60]. 3. GLUT2, a transporter that carries glucose to the liver kidneys and pancreas [59, 60]. 4. GLUT1 is important, in the fact that it carries glucose to the brain cell (neuron and glia cells)

Charmin Toilet Paper Ad -- Advertisement, Ads, Advertising

Advertisements are one of many things that Americans cannot get away from. Every American sees an average of 3,000 advertisements a day; whether it’s on the television, radio, while surfing the internet, or while driving around town. Advertisements try to get consumers to buy their products by getting their attention. Most advertisements don’t have anything to do with the product itself. Every company has a different way of getting the public’s attention, but every advertisement has the same goal - to sell the product. Every advertisement tries to appeal to the audience by using ethos, pathos, and logos, while also focusing on who their audience is and the purpose of the ad. An example of this is a Charmin commercial where there is a bear who gets excited when he gets to use the toilet paper because it is so soft. In this Charmin commercial, the author is the Charmin Company. The bears are used as the speakers for Charmin. They are cute, lovable, and are appealing to most people. They were not always in the Charmin commercials however. The first Charmin bear was introduced in 2001, and then the cubs the following year. They were a big hit with the public so the company continues to use them as the mascots/speakers for Charmin toilet paper. The bears are a big help in selling the product. The audience of the Charmin commercials is every human being that watches television. This product, toilet paper, is something that everyone, no matter where they live, needs to use in everyday life. It is a product that will always be bought by people but there are many different companies in the toilet paper industry. The main audience is for those that do not use Charmin already, but... ... author, or speaker does not use any facts or logic in the commercial. Every advertisement has different ways of getting the audience’s attention. Advertisements mostly use the three appeals, but different forms of showing them off. In this commercial ethos and pathos is used to get to the consumers. Charmin is the greatest toilet paper and everybody should use it, that is the message they are trying to get across. It may be true to some people, but the overall population most likely does not use Charmin but another brand of toilet paper that is cheaper. I do not think that this commercial is that effective because I, along with many other people, just use whatever kind of toilet paper there is; the brand does not matter. In other countries there are other brands that are said to be the number one brand of toilet paper; it is different everywhere.

How does Kant support God’s existence? Essay

Immanuel Kant feels that no-one, human or otherwise, can â€Å"know† that God exists. This is due to various flaws and necessities for humanity. For one, when we cannot have an a posteriori proof for God’s existence due to the fact that it is completely dependent on our personal experience of the world and, therefore, our senses. This is not to be relied upon as we can never see the world for what it really is; only what it appears to us. Kant names the real world, the world we cannot see, the Noumenal World. The world which we perceive through our senses is known to him as the Phenomenal World. The Phenomenal World is the way it is as we cannot help but see the world in a spatio-temporal state of mind, as we are spatio-temporal beings ourselves. The Noumenal World is inexperienceable to us because it really is completely unknowable. Therefore, we cannot know God’s existence as we cannot make correct a posteriori arguments for it, due to our biased and incorrect perception of the world around us. However, Kant also feels that God must always remain a â€Å"necessary postulate of practical reason†. This means that although we cannot, in any way, prove God’s existence, the world will only ever make sense if we postulate, or assume, that God exists. Kant also felt that God’s existence is beyond the experience of our five senses, and so we cannot ever know that He exists through either our senses and, through them, our mind. It is amongst these principles that Kant’s â€Å"moral† argument for the existence of God is based. Kant’s argument for the existence of God is as follows: firstly, it must be understood that the aim of all morality is the â€Å"Summum Bonum†, or the highest good. This highest good is both moral perfection and perfect happiness. For the Summum Bonum to be achieved, these must both be present, as one cannot be without the other. Morality, a universal concept, demands of us that we must aim for this Summum Bonum. We must all strive to be perfectly good, attain moral perfection and the perfect happiness. However, we cannot possibly achieve this ultimate good. This is due to the fact that we are flawed, weak and contingent beings, prone to mistakes and filled with imperfections. Although we may be able to strive towards virtue in our thought and conduct, we cannot achieve true happiness along with it to ensure perfection. We cannot achieve what we deserve for our efforts because we are not omnipotent. Therefore, we cannot hope to achieve this Summum Bonum. However, in Kant’s point of view, â€Å"ought implies can†. This means that if we are obliged to achieve the Summum Bonum, or highest good, then it must mean that it is achievable. Kant says it is â€Å"a necessity connected with duty as a requisite to presuppose the possibility of this highest good†. This means that because we are required by our sense of duty to try to bring about the Highest Good, it must, therefore, be a possibility; it must be attainable. However, this poses a natural contradiction: we cannot possibly hope to do something, and yet we are expected to do it, because we can. This means that we cannot achieve this ultimate good alone, but we must have outside help, from an external and omnipotent agency, or God. We also have an unlimited time to achieve this good in, immortality, which gives way to a definite afterlife. â€Å"Therefore†, Kant concludes, â€Å"it is morally necessary to assume the existence of God†. In this argument, there are two major assumptions upon which the argument rests upon. These are that, firstly, there is an absolute moral order within the world. This is shown to us through both the Bible and Church teachings. Another of the major assumptions is that we, humanity as a whole, are responsible to some transcendent self, in our unconsciousness. This means that we do not feel guilt, do to morality, to our superior, equals or inferiors in society. Rather, all our guilt is towards God. We all account towards him. Therefore, although Kant feels that we cannot possibly prove God’s existence, he feels that His existence must be a necessary postulate for the world to make sense. He, therefore, doesn’t necessarily make sense of God’s existence and support it using his moral argument, but, instead, he uses it to make sense of, and support, morality and why it exists. He had no intention of ever arguing towards the existence of God. Instead he vehemently opposed it, using our senses as our drawback in our arguments.

Community Corrections Paper Essay

When people think of community corrections they may imagine offenders coexisting with the community. To some this is cause for immediate alarm, but community corrections is happening all around us every day, and in many cases, community corrections is actively effective. Community corrections is practiced in countries other than the United States, and impacts each community it is practiced in. It was the late 70s, when officials finally began to take a deeper look into other ways to handle offenders besides the obvious. With growing prison and jail populations, and institutions filling up with first time offenders, offenders convicted of nonviolent crimes, and misdemeanors, many states determined that under proper limitations and regulations, many nonviolent and petty offenders could be maintained securely in their homes, or in halfway homes. These offenders could check in daily to drug treatment programs reporting centers, or community service centers. This notion is what helped ins pire the community corrections programs of today. The practice of community programs is beneficial to both offenders, and the communities they return to. The offender learns accountability in the sense that they learn to be responsible for their time and what they do within that time. Communities are impacted by community corrections in a partially indirect way. The community can claim those who successfully complete the community corrections programs, and utilize the resource provided by the programs, as law abiding and productive citizens of the community. Thus these offenders will no longer pose a threat to the community. My theory about community corrections and their overall effectiveness within the correctional system  is community corrections will evolved and find more efficient ways to help offenders become productive members of society. I imagine the evolution of community corrections programs will be a slow process, but I feel that it is with evolution and innovativeness during evolution that community corrections programs will improve there effectiveness. The United States is not the only country that focuses on humane treatment of prisoners, and rehabilitation within the prison system. Places like Norway, and Indonesia have a prison system that focus es on treatment and rehabilitation through programs. A prison in Norway has been accused of making the prions experience too cushy. Bastoy is equipped with a church, a library, and working toilets in the cells. What many in Norway view as a luxury some would consider necessity. Despite debates about the prisoner treatment in Norway prisons, this area of Europe has the lowest reoffending rate in Europe, and the crimes rates in this area of the world remain at an all-time, low, (James, 2013). Prisons in Indonesia view what they do as a service to the prisoner, and the public. According to the Forgiven Prisoner Support service, (2013), â€Å"services are offered to prisoners in the form of drug and substance abuse and rehabilitation services†, (p, 1). These efforts are specifically aimed at ensuring that the prisoners will be able to live a fulfilling and law abiding life after their release from prison. Considering that all of the prisons I researched seemed to focus on rehabilitation and treatment of prisoners, rather than stern and harsh punishment. During my research I found that it is not apparent that the United States’ prison system would be greatly if affected if it were to focus on imprisonment under the terms that foreign countries seem to focus on. Rehabilitation seems to be the recurring topic when referring to prison systems in this country, as well as others. In the end, it all comes down to the fact that community corrections programs are effective in many cases. If I were to suggest a community corrections program in my neighborhood, I would suggest a program that provides an opportunity for offenders to maintain work within the community. I would suggest projects that include cleaning dilapidated buildings and structures as a sort of beautification project. I would suggest these types of projects within the community that the offender  lives. I would suggest this type of program because I feel that if offenders played a part in cleaning up their communities they may be less likely to commit acts that will bring their communities down. This type of community correction would help build pride in the offender for where they live, and would make them what to keep the area nice. Community corrections is a reputable tool used to aid in the criminal justice system’s struggle to keep offenders functioning as active members of the comm unity. Countries all across the world have the same central focus, which is rehabilitation and treatment for prisoners. It is not plausible that so many prisons systems in the world have it all wrong with their treatment and rehabilitation approach. While some may question the effectiveness of community corrections, the active programs and growing implementation of community corrections in prison system across the country indicate that these programs indeed yield valid and tangible results for those who participate and complete them. References; James, E. (2013). Norwegian Prison. Retrieved from http://www.guardian.co.uk/society/2013/feb/25/norwegian-prison-inmates-treated-like-people Foreign Prisoner Support Service. (2012). News at Foreign Prisons. Retrieved from http://www.foreignprisoners.com/prison-indonesia.html

Essential Gear for Boarding School

Essential Gear for Boarding School Youre off to boarding school. What a great adventure! Yes, it is kind of scary leaving your own home and moving into a strange place. But think of it this way: its all going to be new, different and exciting! And you are doing this before most kids do since most kids leave home for the first time when they go to college. So, what should you bring from home? Well, the school will provide you with a very detailed list of items they want you to bring, and we have a list of essential items for you here. Make sure you have all that stuff. But what else might you need? Check out this list of boarding school gear that will help make your experience even better. 1. Music Most students just cannot live without their tunes. If youre the same way, make sure to load up your iTunes list with the latest music or get a subscription to Pandora, Spotify or another music service. Dont forget to pack whatever  charger you need or even some portable  speakers. An extra set of earbuds couldnt hurt, as well as a set of nice noise canceling headphones. You never know when theres going to be a loud night on dorm and you want to get some homework done or head to bed early, and escaping with your favorite music can be exactly what you need. Bring whatever patch cables you need to hook it all up, too. 2. Laptop and Printer The school will probably specify the kind of laptop you need to bring. It may even be part of your first yearbook fees. In any case, you will need your laptop together with any essential CDs such as the operating system/restore disk, your anti-virus software, etc. A multi-function printer is worth its weight in gold. A USB hub will be useful to connect all your peripherals. Make sure you have all the required dongles and cords to make everything connect, and you might even consider purchasing an extra charger. That way, you can leave one charger in your dorm room and leave one in your bag just in case.   3. Sports Equipment Skates, skis, soccer cleats, golf clubs, tennis and squash racquets, swim goggles, saddle, riding crop and boots. Any of all of these items could be on your list depending on the season and the location of your school. It doesnt all have to come with you; you can always order things online and have them delivered to campus. Or, just make sure you have the sports equipment you need for the fall semester. You can pick up the rest when you go home for breaks and holidays. 4. Cellphone While there will be rules about when and where you can use your cell phone, you will need it. Make sure your service plan allows for unlimited texting and nationwide calling. Dont forget the charger and maybe bring a few. You might consider purchasing an external charger to keep you powered as you go along. A good case can also protect your phone against cracking and chipping.   5. Credit and ATM Card Most schools will give you an opportunity to get an account set up with a local bank, if you need one, which will provide you with an ATM card. Your school may also provide a campus purchasing plan through a one-card system or similar set up. But, you may also want to consider having a separate  credit card for those unexpected emergencies. Use it sparingly for casual purchases only, and make sure you and your parents have a clear understanding about how much you can spend per month. Have an ATM card as well. To prevent fraud have your parents keep a nominal amount in the account the ATM card draws against. They can always add more funds as necessary.

Geog Essay Example | Topics and Well Written Essays - 1000 words

Geog - Essay Example Indeed, two rounds of the longest African civil war in Sudan cost the lives of 1.5 million people; continuing conflict in the western region of Darfur has driven two million people from their homes and killed more than 200,000; famine and drought in the 1980th displaced millions; nobody knows how many lives and migrants it will take to end the south-north confrontation. The statistic of refugees in the Africa shows that Sudan is on top in the list of receiving countries with Zambia, Uganda, Kenya, DR Congo, Guinea and on the top countries of origin of the refugees with Burundi, Angola, Somalia and DR Congo (Tabutin, Schoumaker 510). I think the most appropriate way to define the immigration/emigration patterns is to solve two problems. First of all, I’ll try to show the general political and economical line of Sudan history in the past 50 years. Secondly, I’ll divine country into four border regions - north, east, west and south – and analyze each region. Sudanâ €™s history began in 1956, after the declaration of independence from British-Egypt rule. Northern Muslims took majority in government and didn’t want to deal with South. Consequently, the first civil war has begun. During the war had happened few coups and in 1972 was signed Addis Ababa Agreement that established the  Southern Sudan Autonomy. ... So, political instability provoked mass demographical emigration and intensive mass in-migration. The economic policy was very ineffective. After 1956, independent government followed the colonial type of economy by assigning more land to both public and private sectors for export-oriented production. Government created new economy on the lands that were previously inhabited and cultivated by indigenous population. Besides, many nomadic tribes lost their historical places. That’s why a lot of peasants and nomads were forced to shift their homes and styles of living to urban centers looking for food and water (Eltigani â€Å"War and Drought†¦Ã¢â‚¬  29). Another big failure in economy of the Jaafar Nimeiri regime (1969-1985) was famine in the 1980s. In 1971, Sudan launched a plan for development to turn the country into the "bread-basket" of the Arab world (Ragnhild 202). But, instead, economy declined because of price falling on the world marker. The Sudan's few export p roducts were seriously affected by falling prices on the world market. The uneven distribution of development activities, the drought that hit the western and eastern parts of the country during the mid-1980s also forced millions of people to leave their homes. After the Omar al-Bashir coupe in 1989, policy of islamization continued and the problems with the separatist movements in south and Darfur remained. Darfur is the western region, near Chad, with strong local elites that want more power and decentralization of the Sudan. In 2003 Darfur conflict was accompanied with mass murders, genocide, thousands of refugees. In 2005 the rebels signed a peace deal with the government to end the civil war. To sum up the survey of leading events in Sudan during the